原创力文档alpinia pricei rhizome extracts induce cell cycle arrest in human squamous carcinoma kb cells and suppress tumor growth in nude micepricei粉末成分提取物诱导细胞周期阻滞在人类鳞状细胞癌kb细胞和抑制裸体小鼠肿瘤的生长.pdfVIP
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alpinia pricei rhizome extracts induce cell cycle arrest in human squamous carcinoma kb cells and suppress tumor growth in nude micepricei粉末成分提取物诱导细胞周期阻滞在人类鳞状细胞癌kb细胞和抑制裸体小鼠肿瘤的生长
Hindawi Publishing Corporation
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 123815, 11 pages
doi:10.1093/ecam/nep142
Original Article
Alpinia pricei Rhizome Extracts Induce Cell Cycle Arrest in
Human Squamous Carcinoma KB Cells and Suppress Tumor
Growth in Nude Mice
You-Cheng Hseu,1 Chih-Sheng Chen,2 and Sheng-Yang Wang3
1 Department of Cosmeceutics, College of Pharmacy, China Medical University, 91 Huseh-Shih Road, Taichung 40402, Taiwan
2 Institute of Nutrition, China Medical University, Taichung 40402, Taiwan
3 Department of Forestry, National Chung Hsing University, Taichung 40402, Taiwan
Correspondence should be addressed to You-Cheng Hseu, ychseu@.tw
Received 21 January 2009; Accepted 30 August 2009
Copyright © 2011 You-Cheng Hseu et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Alpinia pricei has been shown to induce apoptosis in human squamous carcinoma (KB) cells. In this study, we report the
effectiveness of the ethanol (70%) extracts of A. pricei rhizome (AP extracts) in terms of tumor regression as determined using both
in vitro cell culture and in vivo athymic nude mice models of KB cells. We found that the AP extract (25–200 μg/mL) treatment
decreased the proliferation of KB cells by arresting progression through the G2/M phase of the cell cycle. This cell cycle blockade
was associated with reductions in cyclin A and B1, Cdc2, and Cdc25C, and increased p21/WAF1, Wee1, p53 and phospho-p53
(p-p53) in a dose- and time-dependent manner. Moreover, we found that AP extract treatment decreased metalloproteinase-9
(MMP-9) and u
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