altered peroxisome-proliferator activated receptors expression in human endometrial cancer改变peroxisome-proliferator激活受体表达在人类子宫内膜癌.pdfVIP

Hindawi Publishing Corporation PPAR Research Volume 2012, Article ID 471524, 5 pages doi:10.1155/2012/471524 Research Article Altered Peroxisome-Proliferator Activated Receptors Expression in Human Endometrial Cancer Paweł Knapp,1 Adrian Chabowski,2 Agnieszka Błachnio-Zabielska,2 Katarzyna Jarza¸bek,3 ´ 3 and Sławomir Wołczynski 1 Department of Gynecology, Medical University of Bialystok, 15-222 Bialystok, Poland 2 Department of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland 3 Department of Gynecological Endocrinology, Medical University of Bialystok, 15-276 Bialystok, Poland Correspondence should be addressed to Adrian Chabowski, adrian@.pl Received 11 July 2011; Revised 7 November 2011; Accepted 21 November 2011 Academic Editor: Ruth Roberts Copyright © 2012 Paweł Knapp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Peroxisome proliferator-activated receptors (PPARs) belong to a family of nuclear hormone receptors acting as transcriptional factors, recently involved also in carcinogenesis. Present study was undertaken to evaluate the presence and subcellular localization of different PPAR isoforms (α, β, γ) in healthy endometrial tissue (n = 10) and endometrial carcinoma (FIGO I, endometrioides type, G1, n = 35). We sought to analyze PPARs mRNA content as well as protein immunohistochemical expression that was further quantified by Western Blot technique. For both PPARα and PPARβ, protein expression was significantly higher in endometrial cancers compared to normal endometrial mucosa. In