additional common polymorphisms in the pon gene cluster predict pon1 activity but not vascular disease附加在其常见的多态性基因簇预测pon1活性但不是血管疾病.pdfVIP

Hindawi Publishing Corporation Journal of Lipids Volume 2012, Article ID 476316, 11 pages doi:10.1155/2012/476316 Research Article Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease Daniel S. Kim,1 Amber A. Burt,2 Jane E. Ranchalis,2 Rebecca J. Richter,2 Julieann K. Marshall,2 Jason F. Eintracht,3 Elisabeth A. Rosenthal,2 Clement E. Furlong,1, 2 and Gail P. Jarvik1, 2 1 Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA 2 Department of Medicine, Division of Medical Genetics, University of Washington School of Medicine, P.O. Box 357720, Seattle, WA 98195, USA 3 Department of General Medicine, Virginia Mason Medical Center, Seattle, WA 98101, USA Correspondence should be addressed to Gail P. Jarvik, gjarvik@ Received 1 January 2012; Accepted 14 March 2012 Academic Editor: Bianca Fuhrman Copyright © 2012 Daniel S. Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Paraoxonase 1 (PON1) enzymatic activity has been consistently predictive of cardiovascular disease, while the genotypes at the four functional polymorphisms at PON1 have not. The goal of this study was to identify additional variation at the PON gene cluster that improved prediction of PON1 activity and determine if these variants predict carotid artery disease (CAAD). Methods. We considered 1,328 males in a CAAD cohort. 51 tagging single-nucleotide polymorphisms (tag SNPs) across the PON cluster were evaluated to determine their effects on PON1 activity and CAAD status. Results. Six SNPs (four in PON1 and