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Hindawi Publishing Corporation Interdisciplinary Perspectives on Infectious Diseases Volume 2010, Article ID 709791, 6 pages doi:10.1155/2010/709791 Review Article Animal Models of CNS Viral Disease: Examples from Borna Disease Virus Models Marylou V. Solbrig Department of Internal Medicine (Neurology) and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada R3A 1R9 Correspondence should be addressed to Marylou V. Solbrig, msolbrig@ Received 1 October 2009; Accepted 8 December 2009 Academic Editor: Guey Chuen Perng Copyright © 2010 Marylou V. Solbrig. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Borna disease (BD), caused by the neurotropic RNA virus, Borna Disease virus, is an affliction ranging from asymptomatic to fatal meningoencephalitis across naturally and experimentally infected warmblooded (mammalian and bird) species. More than 100 years after the first clinical descriptions of Borna disease in horses and studies beginning in the 1980’s linking Borna disease virus to human neuropsychiatric diseases, experimentally infected rodents have been used as models for examining behavioral, neuropharmacological, and neurochemical responses to viral challenge at different stages of life. These studies have contributed to understanding the role of CNS viral injury in vulnerability to behavioral, developmental, epileptic, and neurodegenerative diseases and aided evaluation of the proposed and still controversial links to human disease. 1. Introduction behavior, and aid in testing the hypothesis that BDV may be a