animal experimental study of the fully biodegradable atrial septal defect (asd) occluder完全可生物降解的心房中隔缺损的动物实验研究(asd)遮光板.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 735989, 10 pages doi:10.1155/2012/735989 Research Article Animal Experimental Study of the Fully Biodegradable Atrial Septal Defect (ASD) Occluder Yu-feng Zhu, Xin-miao Huang, Jiang Cao, Jian-qiang Hu, Yuan Bai, Hai-bing Jiang, Zhao-feng Li, Ying Chen, Wei Wang, Yong-wen Qin, and Xian-xian Zhao Department of Cardiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China Correspondence should be addressed to Yong-wen Qin, qyongwen@ Received 14 June 2012; Revised 7 August 2012; Accepted 7 August 2012 Academic Editor: George E. Plopper Copyright © 2012 Yu-feng Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This study was conducted to evaluate the feasibility, safety, biocompatibility, and degradation features of a fully biodegradable occluder for closure of atrial septal defect (ASD) in an acute canine model. The ASD was created in 20 healthy mongrel dogs by the brockenbrough needle, and the fully biodegradable occluders were implanted by self-made delivery system. The success rate and complications were observed. Acute ASD models were successfully created in 18 dogs, and 16 occluders were successfully implanted in the ASD models. Animals were sacrificed at different times after procedure. The cardiac gross anatomy showed that all occluders were stable in the interatrial septum, no vegetation or thrombus formation was observed on the surface of all occluders. They were embedded into endogenous host tissue gradually at 12-week follow-up. Different periods of pathological observations suggested