anti-inflammatory and immune-regulatory effects of subcutaneous perillae fructus extract injections on ova-induced asthma in mice抗炎和免疫调节作用的皮下perillae果实提取物对ova-induced哮喘小鼠注射.pdfVIP

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anti-inflammatory and immune-regulatory effects of subcutaneous perillae fructus extract injections on ova-induced asthma in mice抗炎和免疫调节作用的皮下perillae果实提取物对ova-induced哮喘小鼠注射.pdf

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anti-inflammatory and immune-regulatory effects of subcutaneous perillae fructus extract injections on ova-induced asthma in mice抗炎和免疫调节作用的皮下perillae果实提取物对ova-induced哮喘小鼠注射

Advance Access Publication 8 November 2007 eCAM 2010;7(1)79–86 doi:10.1093/ecam/nem118 Original Article Anti-inflammatory and Immune-regulatory Effects of Subcutaneous Perillae Fructus Extract Injections on OVA-induced Asthma in Mice 1 2 2 2 2 Yun-Kyoung Yim , Hyun Lee , Kwon-Eui Hong , Young-Il Kim , Seung-Kyoung Ko , Jung-Eun Kim1, Seung-Yong Lee1 and Kwang-Suk Park3 1Department of Meridian Acupoint, 2Department of Acupuncture, College of Oriental Medicine, Daejeon University, South Korea, and 3Department of Biomedical Engineering, College of Medicine, Seoul National University, South Korea Perillae fructus (perilla seed) is a traditional medicinal herb used to treat bronchial asthma in Oriental medical clinics. ST36 is one of the most widely used acupuncture points, particularly for immune system regulation. Injection of an herbal extract into an acupuncture point (herbal acupuncture) is a therapeutic technique combining both acupuncture and herbal treatment. Perillae fructus extract was injected subcutaneously (Perillae fructus herbal acupuncture; PF-HA) at acupoint ST36 of OVA-induced asthmatic mice. The lung weight, bronchoalveolar fluid (BALF) cell count, the number of CCR3+, CD11b+, CD4+ and CD3e+/CD69+ cells in the lung, and the level of IgE, IL-4, IL-5 and IL-13 in BALF