anti-inflammatory effects of inonotus obliquus in colitis induced by dextran sodium sulfate抗炎作用的纤孔菌属obliquus在结肠炎引起的葡聚糖硫酸钠.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2010, Article ID 943516, 5 pages doi:10.1155/2010/943516 Research Article Anti-Inflammatory Effects of Inonotus obliquus in Colitis Induced by Dextran Sodium Sulfate Se Young Choi, Sun Jin Hur, Chi Sun An, Yun Hui Jeon, Young Jun Jeoung, Jong Phil Bak, and Beong Ou Lim Department of Life Science, College of Biomedical Health Science, Konkuk University, Chungju 380-701, South Korea Correspondence should be addressed to Beong Ou Lim, beongou@kku.ac.kr Received 15 July 2009; Accepted 6 January 2010 Academic Editor: Yong Lim Copyright © 2010 Se Young Choi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A total of 28 male BALB/c mice (average weight 20.7 ± 1.6 g) were divided into 4 treatment groups and fed a commercial diet (A), a commercial diet + induced colitis by dextran sodium sulfate (DSS) (B), Inonotus obliquus (IO) administration (C), and IO administration + induced colitis by DSS (D). IO treatment (C, D) decreased the expression of tumor necrosis factor (TNF)-α and signal transducers and activators of transcription (STAT)1 compared to those of the colitis induced group (B). The expressions of IL-4 and STAT6 were decreased in group D compared to the colitis induced group (B). The serum immunoglobulin (Ig)E level decreased in IO treatment groups (C, D) compared to no IO treatment groups (A and B) although there was no significant difference between the IO treatment groups. Extract from IO itself had a weak cytotoxic effect on murine macrophage cell line (RAW264.7 cells). Extract from IO inhibited lipopolysacch