antinociceptive activities and the mechanisms of anti-inflammation of asiatic acid in miceantinociceptive活动和亚细亚酸对小鼠的抗炎机制.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 895857, 10 pages doi:10.1155/2011/895857 Research Article Antinociceptive Activities and the Mechanisms of Anti-Inflammation of Asiatic Acid in Mice Shyh-Shyun Huang,1 Chuan-Sung Chiu,1, 2 Hsien-Jung Chen,3 Wen-Chi Hou,4 Ming-Jyh Sheu,5 Ying-Chih Lin,6 Pei-Hsin Shie,1 and Guan-Jhong Huang1 1 School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan 2 Nursing Department, Hsin Sheng College of Medical Care and Management, Taoyuan 325, Taiwan 3 Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan 4 Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan 5 School of Pharmacy, China Medical University, Taichung 404, Taiwan 6 Department of Optometry, Jen-Teh Junior College of Medicine, Nursing, and Management, Miaoli 356, Taiwan Correspondence should be addressed to Guan-Jhong Huang, gjhuang@.tw Received 27 August 2010; Revised 17 January 2011; Accepted 8 February 2011 Copyright © 2011 Shyh-Shyun Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Asiatic acid (AA), a pentacyclic triterpene compound in the medicinal plant Centella asiatica, was evaluated for antinociceptive and anti-inflammatory effects. Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. In the anti-inflammatory test, AA decreased the paw edema at the 4th