antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide抗氧化防御酶保护继承的胎盘和胎儿胎盘血栓形成倾向于过氧化氢.pdfVIP

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antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide抗氧化防御酶保护继承的胎盘和胎儿胎盘血栓形成倾向于过氧化氢.pdf

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antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide抗氧化防御酶保护继承的胎盘和胎儿胎盘血栓形成倾向于过氧化氢

[Oxidative Medicine and Cellular Longevity 2:1, 14-18; January/February/March 2009]; ©2009 Landes Bioscience Research Paper Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide 1 1 2 2 2 3, Jelena Bogdanovic Pristov, Ivan Spasojevic, Željko Mikovic, Vesna Mandic, Nikola Cerovic and Mihajlo Spasic * 1University of Belgrade; Institute for Multidisciplinary Research; Department of Biophysics; Belgrade, Serbia; 2Department of Pathological Pregnancy; Clinical Centre for Obstetrics and Gynecology; Belgrade, Serbia; 3University of Belgrade; Institute for Biological Research; Department of Physiology; Belgrade, Serbia Key words: oxidative stress, placenta, hydrogen peroxide, thrombophilia, antioxidative defense, catalase, glutathione 9 Our aim was to investigate the activities of antioxidative defense affect the function of placental circulation. All the above implies a enzymes in the placenta, fetal blood and amnion fluid in inherited potential relation between pro-thrombotic conditions in pregnancy thrombophilia. Thrombophilia was associated with nearly three- complicated by thrombophilia and oxidative stress which has not fold increase of activity (p 0.001) of the placental catalase (81.1 been previously clearly linked. Thus, the aim of this study was to ± 20.6 U/mg of proteins in controls and 270.0 ± 69.9 U/mg in assess the role of oxidative stress and to identify the most abundant thrombophilic subjects)