bioincompatible impact of different peritoneal dialysis fluid components and therapeutic interventions as tested in a rat peritoneal dialysis modelbioincompatible不同腹膜透析液组件和治疗干预措施的影响在鼠腹膜透析模式测试.pdfVIP

SAGE-Hindawi Access to Research International Journal of Nephrology Volume 2011, Article ID 742196, 5 pages doi:10.4061/2011/742196 Review Article Bioincompatible Impact of Different Peritoneal Dialysis Fluid Components and Therapeutic Interventions as Tested in a Rat Peritoneal Dialysis Model Andrea W. D. Stavenuiter,1 Karima Farhat,2 Margot N. Schilte,1 Piet M. ter Wee,2 and Robert H. J. Beelen1 1 Department of Molecular Cell Biology and Immunology, H269, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands 2 Department of Nephrology, VU University Medical Center, 1081 BT Amsterdam, The Netherlands Correspondence should be addressed to Andrea W. D. Stavenuiter, a.stavenuiter@vumc.nl Received 24 March 2011; Accepted 1 June 2011 Academic Editor: Hulya Taskapan Copyright © 2011 Andrea W. D. Stavenuiter et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this paper, we describe the impact of different factors contributing to peritoneal incompatibility of PD fluid installation including presence of a catheter, volume loading, and the PD fluid components itself. These factors initiate recruitment and activation of peritoneal immune cells such as macrophages and mast cells, as well as activation of peritoneal cells as mesothelial cells in situ. We provide an overview of PD-associated changes as seen in our rat PD-exposure model. Since these changes are partly reversible, we finally discuss therapeutic strategi