cardioprotective effect of the compound yangshen granule in rat models with acute myocardial infarction保护作用的复合yangshen颗粒与急性心肌梗死大鼠模型.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 717123, 6 pages doi:10.1155/2012/717123 Research Article Cardioprotective Effect of the Compound Yangshen Granule in Rat Models with Acute Myocardial Infarction Xie Ming,1 Wang Tongshen,2 Wu Delin,2 and Zhao Ronghua1 1 Formulary Department, Beijing University of Chinese Medicine, Beijing 100029, China 2 Pharmacology Department, Anhui College of Chinese Medicine, Hefei, Anhui 230000, China Correspondence should be addressed to Xie Ming, xieming603@263.net Received 10 October 2011; Revised 28 December 2011; Accepted 10 January 2012 Academic Editor: Hao Xu Copyright © 2012 Xie Ming et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The protective effect of Compound Yangshen Granules was observed in myocardial infarction rat model. Rats were randomly divid- ed into 6 groups: the model group, the control group (sham operated), the positive drug group, and small, medium, and large dos- age of the Yangshen granule groups, respectively. The rats in the 3 Yangshen granule groups were orally administrated with 0.7 g/kg, 1.4 g/kg, and 2.8 g/kg for 7 consecutive days, whereas the rats of the positive drug group treated with 0.14 g/kg of Danshen Dropping Pills, and rats in the control and model groups orally administrated with saline. The rat model of acute myocardial infarction was established with ligation of coronary artery. Electrocardiograms at different time points, the blood rheology, myocardial enzymes, infarct size, and myocardial morphologic changes were measured. The results demonstrated that the granules could