renal involvement in preeclampsia similarities to vegf ablation therapyvegf消融治疗肾参与子痫前期相似之处.pdf

Hindawi Publishing Corporation Journal of Pregnancy Volume 2011, Article ID 176973, 6 pages doi:10.1155/2011/176973 Review Article Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy ¨ Janina Muller-Deile and Mario Schiffer Division of Nephrology and Hypertension, Department of Medicine, IFB-TX Hannover, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany Correspondence should be addressed to Mario Schiffer, schiffer.mario@mh-hannover.de Received 11 September 2010; Accepted 1 November 2010 Academic Editor: David F. Lewis ¨ Copyright © 2011 J. Muller-Deile and M. Schiffer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy. 1. Introduction pronounced for VEGF since its serum level was not as hi