retinoblastoma as an epigenetic disease a proposal视网膜母细胞瘤是一种表观遗传疾病的建议.pdfVIP

Journal of Cancer Therapy, 2011, 2, 362-371 doi:10.4236/j ct.2011.23049 Published Online August 20 11 (http://www.SciRP.org/journal/jct ) Retinoblastoma as an Epigenetic Disease: A Proposal Domenico Mastrangelo, Cosimo Loré, Giovanni Grasso Department of Biomedical Sciences, University of Siena, Siena, Italy. Email: mastrangelo@unisi.it Received May 6th, 2011; revised July 15th, 2011; accepted July 25th, 20 11. ABSTRACT The aim of the present review is to give new insights into the pathogenesis of retinoblastoma, by applying the principles of Epigenetics to the analysis of clinical