role of ghrelin in modulation of s-nitrosylation-dependent akt inactivation induced in salivary gland acinar cells by porphyromonas gingivalis激素作用的调制s-nitrosylation-dependent akt在唾腺腺泡细胞失活引起porphyromonas gingivalis.pdf

Vol.2, No.12, 1448-1455 (2010) Health doi:10.4236/health.2010.212215 Role of ghrelin in modulation of S-nitrosylation- dependent Akt inactivation induced in salivary gland acinar cells by Porphyromonas gingivalis Bronislaw L. Slomiany*, Amalia Slomiany Research Center, University of Medicine and Dentistry of New Jersey, Newark, USA; *Corresponding Author: slomiabr@ Received 23 August 2010; revised 8 October 2010; accepted 26 October 2010 ABSTRACT S-Nitrosylation; cNOS Phosphorylation; Ghrelin Ghrelin, a peptide hormone, newly identified 1. INTRODUCTION in oral mucosal tissue, has emerged re- cently as a principal modulator of the in- Recent advances in understanding the nature of fac- flammatory responses to bacterial infection tors that influence the extent of mucosal inflammatory through the regulation of nitric oxide syn- responses along the alimentary tract, including that of thase system. In this study, using rat sub- oral cavity, have brought to focus the importance of a lingual salivary gland acinar cells, we report peptide hormone, ghrelin [1-4]. This 28-amino acid pep- that lipopolysaccharide (LPS) of periodon- tide, initially isolated from the stomach [1,2], and more topathic bacterium, P. gingivalis- induced recently identified in oral mucosa, saliva and the acinar enhancement in the activity of inducible ni- cells of salivary glands [3], has emerged as a principal tric oxide synthase (iNOS) was associated