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role of nkt cells in the pathogenesis of nafldnkt细胞在非酒精性脂肪肝的发病机制中的作用
Hindawi Publishing Corporation
International Journal of Hepatology
Volume 2012, Article ID 850836, 6 pages
doi:10.1155/2012/850836
Review Article
Role of NKT Cells in the Pathogenesis of NAFLD
Kazuto Tajiri1 and Yukihiro Shimizu2
1 The Third Department of Internal Medicine, Toyama University Hospital, Toyama, Toyama 930-0194, Japan
2 Gastroenterology Unit, Takaoka City Hospital, Takaoka, Toyama 933-8550, Japan
Correspondence should be addressed to Yukihiro Shimizu, rsf14240@
Received 9 November 2011; Revised 12 January 2012; Accepted 23 January 2012
Academic Editor: Manuela Neuman
Copyright © 2012 K. Tajiri and Y. Shimizu. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
Nonalcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease and shows various inflammatory changes in the
liver. Among those inflammatory cells, natural killer T (NKT) cells are found to have a critical role during the disease progression.
NKT cells may have a protective role at the early stage with simple steatosis through modification of insulin resistance, whereas
they act as a progression factor at the advanced stage with fibrosis. Those processes are thought to depend on interaction between
NKT cells and CD1d molecule in the liver.
1. Introduction 2. Hepatic NKT Cells and Their Role in
the Pathogenesis of Liver Diseases
Nonalcoholic fatty liver disease (NAFLD) is the most fre-
quent chronic liver disease in the world [1]. NAFLD shows 2.1. NKT Cells in the Liver.
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