scientific basis for the potential use of melatonin in bone diseases osteoporosis and adolescent idiopathic scoliosis科学依据的潜在使用褪黑激素在骨骼疾病,骨质疏松症和青少年特发性脊柱侧凸.pdf

SAGE-Hindawi Access to Research Journal of Osteoporosis Volume 2010, Article ID 830231, 10 pages doi:10.4061/2010/830231 Review Article Scientific Basis for the Potential Use of Melatonin in Bone Diseases: Osteoporosis and Adolescent Idiopathic Scoliosis ´ ´ 1 1 2 2 E. J. Sanchez-Barcelo, M. D. Mediavilla, D. X. Tan, and R. J. Reiter 1 Department of Physiology Pharmacology, School of Medicine, University of Cantabria, 39011 Santander, Spain 2 Department of Cellular Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA ´ ´ Correspondence should be addressed to E. J. Sanchez-Barcelo, barcelo@unican.es Received 25 January 2010; Accepted 3 March 2010 Academic Editor: Joao Lindolfo Borges ´ ´ Copyright © 2010 E. J. Sanchez-Barcelo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The objective of this paper was to analyze the data supporting the possible role of melatonin on bone metabolism and its repercussion in the etiology and treatment of bone pathologies such as the osteoporosis and the adolescent idiopathic scoliosis (AIS). Melatonin may prevent bone degradation and promote bone formation through mechanisms involving both melatonin receptor-mediated and receptor-independent actions. The three principal mechanisms of melatonin effects on bone function could be: (a) the promotion of the osteoblast diffe