serum levels of tnf-, ifn-, il-6, il-8, il-12, il-17, and il-18 in patients with active psoriasis and correlation with disease severity血清肿瘤坏死因子水平、干扰素、白介素,引发,白介素,il-17,地震活跃的牛皮癣患者与疾病严重程度相关.pdf

Mediators of Inflammation • 2005:5 (2005) 273–279 • PII: S0962935105507075 • DOI: 10.1155/MI.2005.273 RESEARCH COMMUNICATION Serum Levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity Ozer Arican,1 Murat Aral,2 Sezai Sasmaz,1 and Pinar Ciragil2 1Department of Dermatology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras 46000, Turkey 2Department of Microbiology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras 46000, Turkey Received 6 June 2005; accepted 27 June 2005 Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. The most often used psoriasis score is the psoriasis area and severity index (PASI). A simple laboratory test from a blood sample would be an attractive, patient-independent, and observer-independent marker of disease severity. To this end, we evaluated the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. The serum levels of cytokines levels were determined with the use of the ELISA method. All mean values except IL-17 levels of patients were significantly higher than those of controls. There was a significant correlation between serum levels of IFN-γ, IL-12, IL-17, and IL-18, and severity of the disease. Psoriasis can be described as a T-cell-mediated disease, with a complex role for a variety of cytokines, which has led to the development of new immunomodulatory therapies. In this study, serum TNF-α, IFN-γ, IL-6, IL-8, IL-12, and IL-18 levels were significantly higher in active psoriatic patients than in controls. Furthermore, high levels of IF