signaling proteins and transcription factors in normal and malignant early b cell development信号蛋白和转录因子在正常和恶性b细胞早期发育.pdfVIP
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signaling proteins and transcription factors in normal and malignant early b cell development信号蛋白和转录因子在正常和恶性b细胞早期发育
Hindawi Publishing Corporation
Bone Marrow Research
Volume 2011, Article ID 502751, 10 pages
doi:10.1155/2011/502751
Review Article
Signaling Proteins and Transcription Factors in Normal and
Malignant Early B Cell Development
´ 1 ´ 1 ´2
Patricia Perez-Vera, Adriana Reyes-Leon, and Ezequiel M. Fuentes-Panana
1 Laboratorio de Cultivo de Tejidos, Departamento de Investigaci´on en Gen´etica Humana,
Instituto Nacional de Pediatr´ıa Insurgentes Sur 3700-C. Col. Insurgentes Cuicuilco, 04530 M´exico, DF, Mexico
2 Unidad de Investigaci´on M´edica en Enfermedades Infecciosas y Parasitarias (UIMEIP),
Hospital de Pediatr´ıa Centro M´edico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauht´emoc 330,
Colonia Doctores, Delegaci´on Cuauht´emoc, 06720 M´exico, DF, Mexico
´
Correspondence should be addressed to Ezequiel M. Fuentes-Panana, empanana@
Received 11 March 2011; Accepted 8 April 2011
Academic Editor: Philip L. McCarthy
´
Copyright © 2011 Patricia Perez-Vera et al. This is an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly
cited.
B cell development starts in bone marrow with the commitment of hematopoietic progenitors to the B cell lineage. In murine
models, the IL-7 and preBCR receptors, and the signaling pathways and transcription factors that they regulate, control
commitment and maintenance along the B cell
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