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sonodynamic antitumor effect of benzoporphyrin derivative monoacid ring a on kln205 cellssonodynamic benzoporphyrin衍生物抗肿瘤效应一元酸环kln205细胞.pdf

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sonodynamic antitumor effect of benzoporphyrin derivative monoacid ring a on kln205 cellssonodynamic benzoporphyrin衍生物抗肿瘤效应一元酸环kln205细胞

Journal of Cancer Therapy, 2011, 2, 99-104 99 doi:10.4236/jct.2011.22011 Published Online June 2011 (http://www.SciRP.org/journal/jct) Sonodynamic Antitumor Effect of Benzoporphyrin Derivative Monoacid Ring A on KLN205 Cells 1,2 1 2 3 2 Tomohiro Osaki , Motoshi Tajima , Yoshiharu Okamoto , Satoshi Takagi , Takeshi Tsuka , Tomohiro Imagawa2, Saburo Minami2 1Veterinary Teaching Hospital, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan; 2Laboratory of Veterinary Surgery, School of Veterinary Clinical Sciences, Faculty of Agriculture, Tottori University, Tottori, Japan; 3Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. Email: tosaki@muses.tottori-u.ac.jp Received February 22nd, 2011; revised May 16th, 2011; accepted May 25th, 2011. ABSTRACT Sonodynamic therapy is a new cancer treatment based on the synergetic effect of ultrasound and a drug. In this study, ultrasonically induced antitumor effects of benzoporphyrin derivative monoacid ring A (BPD-MA) on KLN205 cells were investigated. KLN205 cells were irradiated at an ultrasonic frequency of 3 MHz with 10 μg/ml BPD-MA. The ul- trasonically induced cell damage significantly increased as an ultrasonic intensity and ultrasound exposure time in- creased. Confocal microscopic examination revealed that the irradiated cells were induced chromatin condensation and phosphatidylserine exposure. The synergistic effect of the ultrasound exposure and BPD-MA on the tumor cell ad- hesion rate was significant. Keywords : BPD-MA, Cell Damage, Sonodynamic Therapy, Sonosensitizer, Ultrasound 1. Introduction