stability and feedback stabilization of hiv infection model with two classes of target cells艾滋病毒感染模型的稳定性和反馈稳定两类目标细胞.pdfVIP

Hindawi Publishing Corporation Discrete Dynamics in Nature and Society Volume 2012, Article ID 963864, 20 pages doi:10.1155/2012/963864 Research Article Stability and Feedback Stabilization of HIV Infection Model with Two Classes of Target Cells A. M. Elaiw1, 2 and A. M. Shehata2 1 Department of Mathematics, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia 2 Department of Mathematics, Faculty of Science, Al-Azhar University, Assiut 71511, Egypt Correspondence should be addressed to A. M. Elaiw, a m elaiw@ Received 3 April 2012; Accepted 24 June 2012 Academic Editor: Mingshu Peng Copyright q 2012 A. M. Elaiw and A. M. Shehata. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We study the stability and feedback stabilization of the uninfected steady state of a human immunodeficiency virus HIV infection model. The model is a 6-dimensional nonlinear ODEs that describes the interaction of the HIV with two classes of target cells, CD4 T cells and macrophages, and takes into account the Cytotoxic T Lymphocytes CTLs immune response. Lyapunov function is constructed to establish the global asymptotic stability of the uninfected steady state of the model. In a control system framework, the HIV infection model incorporating the effect of Highly Active AntiRetroviral Therapy HAART is considered as a nonlinear control system with drug dose as control input. We developed treatment schedules for HIV-infected patients by using Model Predictive Control MPC-based method. The MPC is constructed on the