原创力文档Glomerulopathies –IgA nephropathy IgA nephropathy - UMF ：肾小球疾病的免疫球蛋白IgA肾病免疫球蛋白IgA肾病- UMF–.ppt
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Glomerulopathies –IgA nephropathy IgA nephropathy - UMF ：肾小球疾病的免疫球蛋白IgA肾病免疫球蛋白IgA肾病- UMF–
Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis Mesangial IgA ? promotes glomerular inflammation ? a series of events ? ……. ? can cause end stage renal disease Glomerulopathies –IgA nephropathy Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis What specific mechanisms influence the deposition of IgA and its initiation of inflammation? Glomerulopathies –IgA nephropathy Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis tightly T cell controlled processes in health most polymeric IgA is produced in the mucosal immune system is involved in mucosal defense the bone marrow produces monomeric IgA, which reaches the circulation Glomerulopathies –IgA nephropathy Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis in IgA nephropathy synthesis of polymeric IgA is increased in the bone marrow and decreased in the mucosa Glomerulopathies –IgA nephropathy Glomerulopathies –IgA nephropathy Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis Yes it is Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis Why might this happen? This process is very tightly T cell regulated In response to a mucosal antigen, T cells reach the circulation, but will return to the mucosa to synthesize polymeric IgA if they express alpha 4 beta 7, the mucosal homing receptor If on the other hand, a systemic antigen is confronted, T cells will home to the marrow if they express the alpha 4 beta 1 systemic homing receptor Glomerulopathies –IgA nephropathy Glomerulopathies –IgA nephropathy Glomerulopathies –IgA nephropathy IgA nephropathy - Pathogenesis in IgA nephropathy - these processes is abnormal there is an exaggeration of systemic homing receptor expression, which would drive T cells not back to the mucosa but towards the marrow ? the abnormal site of IgA1 production, which is one of the features of IgA nephropa
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