慢性心衰心肌能量代谢调控与运动.PDFVIP

第 16 卷第 4 期 体 育 学 刊 Vol.16 No.4 2009 年 4 月 Journal of Physical Education A p r . 2 0 0 9 慢性心衰心肌能量代谢调控与运动 黄治官，郝选明28 （华南师范大学体育科学学院，广东 广州 510006 ） 摘 要：心肌能量代谢(MEM)障碍与慢性心力衰竭(CHF)发生发展相伴，与病理性心肌肥厚 及心功能异常密切相关。剖析了CHF 病人的MEM 特征，综述了CHF 的MEM 信号分子及调控 通路的研究进展，以及运动干预对CHF 患者的MEM 相关信号调控通路的影响。心肌中AMPK 、 PGC-1α、PKB/Akt 及HIF-1α等通过多条通路，相互协调地调控MEM 。针对CHF 的运动干预可 影响心肌代谢信号分子，对缓解CHF 的能量代谢障碍可能有重要作用，这将是防治CHF 的新思 路。 关 键 词：运动生理学；心血管疾病；慢性心力衰竭；心肌能量代谢调控；运动干预；综述 中图分类号：G804.7 文献标识码：A 文章编号：1006-7116(2009)04-0108-05 Chronically failing myocardial energy metabolism regulation and exercising HUANG Zhi-guan ，HAO Xuan-ming （School of Physical Education，South China Normal University，Guangzhou 510006 ，China ） Abstract: Myocardial energy metabolism (MEM) disorder and chronic heart failure (CHF) are concurrently hap- pening and developing, closely related to pathological myocardial hypertrophy and cardiac dysfunction. The authors dissected the MEM characteristics of CHF patients, and gave an overview of progress made in researches on CHF patient’s MEM signaling molecules and regulating paths, as well as the effects of exercising intervention on CHF patient’s MEM related signal regulating paths. In cardiac muscle AMPK, PGC-1α, PKB/Akt and HIF-1α regulate MEM harmoniously via multiple paths. Exercising intervention of CHF patients may affect MEM signaling mole- cules and play an important role in abating CHF patient’s MEM disorder, which will be a new idea for preventing CHF. Key words: sports physiology ；cardiovascular disease ；chronic heart failure ；myocardial energy metabolism regulation