0905甲状腺癌声学特点与分子标志物及病理类型相关性研究.docVIP

hTERT人端粒酶催化亚单位 VEGF血管内皮生长因子 RET RET原癌基因 P53 P53人体抑癌基因 AJCC 美国癌症联合委员会） AG 平均灰度值 NA 面数密度值 甲状腺癌声学特点与分子标志物及病理类型相关性研究 目的：通过二维超声及彩色多普勒超声血流成像分别观察甲状腺癌组织的声像特征以及甲状腺病灶血流分布情况和淋巴结转移状况，分析其超声表现与hTERT、VEGF、Ret、P53、KI67等多个基因表达情况、肿瘤标记物及病理类型之间的相关性，探讨彩色多普勒超声在甲状腺癌早期诊断及预后评估中的应用价值。方法：选取本院甲状腺癌患者80例，均经术中病理确诊，合并淋巴结转移者30例，均有完整术前超声检查资料，影像质量理想。对所有患者的声像图资料和相关基因、肿瘤标记物及病理类型资料进行比较分析，获取其相关性。结果：80例甲状腺癌的超声声像学特点与其病理类型及相关分子标志物之间存在一定的相关性，不同病理类型的甲状腺癌，其超声诊断符合率不尽相同，其相关分子标志物也呈现不同的表达。结论：不同超声声像图类型的甲状腺癌组织，其病理类型分布有一定的差异，hTERT、VEGF、Ret、P53、KI67等分子标志物的阳性率均较高，但不同声像图类型间仍有一定差异，医师在诊断中应根据具体声像图特点选择免疫组织化学检验方法，并早期判断甲状腺癌的病理类型，实现早诊早治。 关键词：甲状腺癌；超声诊断；病理类型；分子标志物 Study on the Relationship Between the Ultrasonographic Features, Molecular Markers and Pathological Types of Thyroid Cancer [Abstract] Objective: To observe the ultrasonographic features, focal blood distribution and lymph node metastasis of thyroid cancer by 2D ultrasonography and color Doppler flow imagining, and analyse the relationship between ultrasonographic features, molecular markers, pathological types and the translation of several genes such as hTERT, VEGF, Ret, P53. Methods: 80 cases of thyroid cancer confirmed by pathological examination were selected. Ultrasonographic documents were complete and related gene information and molecular markers and pathological documents were compared and analysed. Results: Certain correlation was observed between the ultrasonographic features, focal blood distribution and lymph node metastasis of thyroid cancer of the 80 cases of thyroid cancer. The diagnostic accuracy and the translation of related genes differs from each other. Conclusion: There is some variance among the pathological type distributions of different types of ultrasonographic types of thyroid cancers. The positive rates of hTERT, VEGF, Ret, P53, KI67 are relatively high, however, there is certain variance among different ultrasonographic types. We should select suitable immunohistochemical test to perform early diagnosis and treatment of thyroid cancers. K