a common smad7 variant is associated with risk of colorectal cancer evidence from a case-control study and a meta-analysis共同smad7变体与结直肠癌的风险相关联的证据从一个病例对照研究和荟萃分析.pdfVIP

A Common SMAD7 Variant Is Associated with Risk of Colorectal Cancer: Evidence from a Case-Control Study and a Meta-Analysis 1. 1,2. 1 3 1 1 2 2 Qibin Song , Beibei Zhu , Weiguo Hu , Liming Cheng , Hongyun Gong , Bin Xu , Xiawen Zheng , Li Zou , 2 2 2 2 2 2 Rong Zhong , Shengyu Duan , Wei Chen , Rui Rui , Jing Wu , Xiaoping Miao * 1 Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China, 2 Department of Epidemiology and Biostatistics and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3 Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Abstract Background: A common genetic variant, rs4939827, located in SMAD7, was identified by two recent genome-wide association (GWA) studies to be strongly associated with the risk of colorectal cancer (CRC). However, the following replication studies yielded conflicting results. Method and Findings: We conducted a case-control study of 641 cases and 1037 controls in a Chinese population and then performed a meta-analysis, integrating our and published data of 34313 cases and 33251 controls, to clarify the relationship between rs4939827 and CRC risk. In our case-control study, the dominant model was significant associated with increased CRC risk [Odds Ratio (OR) = 1.46; 95% confidence interval (95% CI), 1.19–1.80]. The following meta-analysis further confirmed this significant association for all genetic models but with significant between-s