原创力文档a community-based study of factors associated with continuing transmission of lymphatic filariasis in leogane, haiti以社区为基础的研究因素与莱继续淋巴丝虫病的传播,海地.pdfVIP
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a community-based study of factors associated with continuing transmission of lymphatic filariasis in leogane, haiti以社区为基础的研究因素与莱继续淋巴丝虫病的传播,海地
A Community-Based Study of Factors Associated with
Continuing Transmission of Lymphatic Filariasis in
Leogane, Haiti
1 1 1 2 3
Alexis Boyd , Kimberly Y. Won *, Shannon K. McClintock , Catherine V. Donovan , Sandra J. Laney ,
3 3 2 4 1
Steven A. Williams , Nils Pilotte , Thomas G. Streit , Madsen V. E. Beau de Rochars , Patrick J. Lammie
1 Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 2 Department of Biological Sciences, University of
Notre Dame, Notre Dame, Indiana, United States of America, 3 Department of Biological Sciences, Smith College, Northampton, Massachusetts, United States of America,
4 Hopital Ste. Croix, Leogane, Haiti
Abstract
Seven rounds of mass drug administration (MDA) have been administered in Leogane, Haiti, an area hyperendemic for
lymphatic filariasis (LF). Sentinel site surveys showed that the prevalence of microfilaremia was reduced to ,1% from levels
as high as 15.5%, suggesting that transmission had been reduced. A separate 30-cluster survey of 2- to 4-year-old children
was conducted to determine if MDA interrupted transmission. Antigen and antifilarial antibody prevalence were 14.3% and
19.7%, respectively. Follow-up surveys were done in 6 villages, including those selected for the cluster survey, to assess risk
factors related to continued LF transmission and to pinpoint hotspots of transmission. One hundred houses were mapped
in each village using GPS-enabled PDAs, and then 30 houses and 10 alternates were chosen for testing. All individuals in
selected houses were asked to participate i
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