原创力文档a confidence interval for the wallace coefficient of concordance and its application to microbial typing methods华莱士和谐系数的置信区间及其应用微生物输入方法.pdfVIP
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a confidence interval for the wallace coefficient of concordance and its application to microbial typing methods华莱士和谐系数的置信区间及其应用微生物输入方法
A Confidence Interval for the Wallace Coefficient of
Concordance and Its Application to Microbial Typing
Methods
1,2 ´ 1 ´ 1
Francisco R. Pinto *, Jose Melo-Cristino , Mario Ramirez
´ ´
1 Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal, 2 Centro de Quımica e Bioquımica, Departamento de
´ ´ ˆ
Quımica e Bioquımica, Faculdade de Ciencias da Universidade de Lisboa, Lisboa, Portugal
Abstract
Very diverse research fields frequently deal with the analysis of multiple clustering results, which should imply an objective
detection of overlaps and divergences between the formed groupings. The congruence between these multiple results can
be quantified by clustering comparison measures such as the Wallace coefficient (W). Since the measured congruence is
dependent on the particular sample taken from the population, there is variability in the estimated values relatively to those
of the true population. In the present work we propose the use of a confidence interval (CI) to account for this variability
when W is used. The CI analytical formula is derived assuming a Gaussian sampling distribution and recurring to the
algebraic relationship between W and the Simpson’s index of diversity. This relationship also allows the estimation of the
expected Wallace value under the assumption of independence of classifications. We evaluated the CI performance using
simulated and published microbial typing data sets. The simulations showed that the CI has the desired 95% coverage when
the W is greater than 0.5. This behaviour is robust to changes in cluster nu
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