原创力文档a computer simulation of progesterone and cox2 inhibitor treatment for preterm labor计算机模拟的孕激素和cox2抑制剂治疗早产.pdfVIP
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a computer simulation of progesterone and cox2 inhibitor treatment for preterm labor计算机模拟的孕激素和cox2抑制剂治疗早产
A Computer Simulation of Progesterone and Cox2
Inhibitor Treatment for Preterm Labor
1,2 3 4 5 1,2 3
Ozlem Equils *, Priya Nambiar , Calvin J. Hobel , Roger Smith , Charles F. Simmons , Shireen Vali
1 Department of Pediatrics, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine
at University of California Los Angeles, Los Angeles, California, United States of America, 2 Medical Division, Pfizer Inc., New York, New York, United States of America,
3 Cellworks Group Inc., Saratoga, California, United States of America, 4 Obstetrics and Gynecology, Cedars-Sinai Medical Center, David Geffen School of Medicine at
University of California Los Angeles, Los Angeles, California, United States of America, 5 Endocrine Unit, Mothers and Babies Research Centre, John Hunter Hospital, Hunter
Medical Research Institute, Newcastle, New South Wales, Australia
Abstract
Background: Sufficient information from in vitro and in vivo studies has become available to permit computer modeling of
the processes that occur in the myometrium during labor. This development allows the in silico investigation of pathological
mechanisms and the trialing of potential treatments.
Methods/Results: Based on the human literature, we developed a computer model of the immune-endocrine environment
of the myometrial cell. The interactions between molecules are represented by differential equations. The model is designed
to simulate the estrogen and progesterone receptor changes during pregnancy and particularly the changes in the
progesterone receptor (PR) isoforms A and B that are thought to mediate functional progesterone w
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