原创力文档a constant light-genetic screen identifies kismet as a regulator of circadian photoresponses一个常数light-genetic屏幕识别kismet昼夜光响应的监管机构.pdfVIP
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a constant light-genetic screen identifies kismet as a regulator of circadian photoresponses一个常数light-genetic屏幕识别kismet昼夜光响应的监管机构
A Constant Light-Genetic Screen Identifies KISMET as a
Regulator of Circadian Photoresponses
¨ 1 1,2¤ 3 1,2
Raphaelle Dubruille , Alejandro Murad , Michael Rosbash , Patrick Emery *
1 Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, 2 Program in Neuroscience, University of
Massachusetts Medical School, Worcester, Massachusetts, United States of America, 3 Howard Hughes Medical Institute, National Center for Behavioral Genetics and
Department of Biology, Waltham, Massachusetts, United States of America
Abstract
Circadian pacemakers are essential to synchronize animal physiology and behavior with the day:night cycle. They are self-
sustained, but the phase of their oscillations is determined by environmental cues, particularly light intensity and
temperature cycles. In Drosophila, light is primarily detected by a dedicated blue-light photoreceptor: CRYPTOCHROME
(CRY). Upon light activation, CRY binds to the pacemaker protein TIMELESS (TIM) and triggers its proteasomal degradation,
thus resetting the circadian pacemaker. To understand further the CRY input pathway, we conducted a misexpression
screen under constant light based on the observation that flies with a disruption in the CRY input pathway remain robustly
rhythmic instead of becoming behaviorally arrhythmic. We report the identification of more than 20 potential regulators of
CRY-dependent light responses. We demonstrate that one of them, the chromatin-remodeling enzyme KISMET (KIS), is
necessary for normal circadian photoresponses, but does not affect the circadian pacemaker. KIS genetically interacts with
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