a core myc gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response核心myc基因表达签名是著名的官腔乳腺癌,但只是部分重叠的核心血清反应.pdfVIP

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2017-09-05 发布于上海
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a core myc gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response核心myc基因表达签名是著名的官腔乳腺癌,但只是部分重叠的核心血清反应.pdf

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a core myc gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response核心myc基因表达签名是著名的官腔乳腺癌,但只是部分重叠的核心血清反应

A Core MYC Gene Expression Signature Is Prominent in Basal-Like Breast Cancer but Only Partially Overlaps the Core Serum Response 1¤a 4,5 2¤b 3 4 Sanjay Chandriani , Eirik Frengen , Victoria H. Cowling , Sarah A. Pendergrass , Charles M. Perou , Michael L. Whitfield3, Michael D. Cole2,3* 1 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America, 2 Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 3 Department of Genetics, Dartmouth Medical School, Lebanon, New Hampshire, United States of America, 4 Department of Genetics and Pathology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, ˚ United States of America, 5 Department of Medical Genetics, Ulleval University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway Abstract Background: The MYC oncogene contributes to induction and growth of many cancers but the full spectrum of the MYC transcriptional response remains unclear. Methodology/Principal Findings: Using microarrays, we conducted a detailed kinetic study of genes that respond to MYCN or MYCNDMBII induction in primary human fibroblasts. In parallel, we determined the response to steady state overexpression of MYCN and MYCNDMBII in the same cell type. An overlapping set of 398 genes from the two protocols was designated a ‘Core MYC Signature’ and used for further analysis. Comparison of the Core MYC Signature to a published study of the genes induced by serum stimulation revealed that only 7.4% of the C