原创力文档a conserved phd finger protein and endogenous rnai modulate insulin signaling in caenorhabditis elegans守恒的博士手指蛋白质和内源性rnai调节胰岛素信号在线虫.pdfVIP
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a conserved phd finger protein and endogenous rnai modulate insulin signaling in caenorhabditis elegans守恒的博士手指蛋白质和内源性rnai调节胰岛素信号在线虫
A Conserved PHD Finger Protein and Endogenous RNAi
Modulate Insulin Signaling in Caenorhabditis elegans
1. 1. 2,3 4 5
Andres R. Mansisidor , Germano Cecere , Sebastian Hoersch , Morten B. Jensen , Trupti Kawli ,
1,6 1 5,7¤ 4 1
Lisa M. Kennedy , Violeta Chavez , Man-Wah Tan , Jason D. Lieb , Alla Grishok *
1 Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America, 2 David H. Koch Institute for Integrative
¨
Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, 3 Bioinformatics Group, Max Delbruck Center for Molecular
Medicine, Berlin, Germany, 4 Department of Biology, Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center, The University of North Carolina
at Chapel Hill, Chapel Hill, North Carolina, United States of America, 5 Department of Genetics, Stanford University, Stanford, California, United States of America,
6 Department of Genetics and Development, Columbia University, New York, New York, United States of America, 7 Department of Microbiology and Immunology,
Stanford University School of Medicine, Stanford, California, United States of America
Abstract
Insulin signaling has a profound effect on longevity and the oxidative stress resistance of animals. Inhibition of insulin
signaling results in the activation of DAF-16
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