原创力文档a cooperative interaction between nontranslated rna sequences and ns5a protein promotes in vivo fitness of a chimeric hepatitis cgb virus b合作互动nontranslated rna序列和ns5a蛋白促进体内嵌合cgb型肝炎病毒b的健身.pdfVIP
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a cooperative interaction between nontranslated rna sequences and ns5a protein promotes in vivo fitness of a chimeric hepatitis cgb virus b合作互动nontranslated rna序列和ns5a蛋白促进体内嵌合cgb型肝炎病毒b的健身
A Cooperative Interaction between Nontranslated RNA
Sequences and NS5A Protein Promotes In Vivo Fitness of
a Chimeric Hepatitis C/GB Virus B
1.¤a 1. 1¤b 2 3¤c 3
Lucile Warter , Lisette Cohen , Yann Benureau , Deborah Chavez , Yan Yang , Francis Bodola ,
3 4¤d 2 1
Stanley M. Lemon , Cinzia Traboni , Robert E. Lanford , Annette Martin *
´ ´ ´ ´ ` ´
1 Institut Pasteur, Unite de Genetique Moleculaire des Virus a ARN, CNRS URA 3015, Universite Paris Diderot - Paris 7 EA 302, Paris, France, 2 Southwest Foundation for
Biomedical Research, Southwest National Primate Research Center, San Antonio, Texas, United States of America, 3 Center for Hepatitis Research, Institute for Human Infections
and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America, 4 Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Italy
Abstract
GB virus B (GBV-B) is closely related to hepatitis C virus (HCV), infects small non-human primates, and is thus a valuable
surrogate for studying HCV. Despite significant differences, the 59 nontranslated RNAs (NTRs) of these viruses fold into four
similar structured domains (I-IV), with domains II-III-IV comprising the viral internal ribosomal entry site (IRES). We previously
reported the in vivo rescue of a chimeric GBV-B (vGB/IIIHC) containing HCV sequence in domain III, an essential segment of the
IRES. We show here that three mutations identified
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