原创力文档a dkp cyclo(l-phe-l-phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterasedkp三轮车(l-phe-l-phe)中发现鸡精是一个二元胺和乙酰胆碱酯酶的抑制剂.pdfVIP
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a dkp cyclo(l-phe-l-phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterasedkp三轮车(l-phe-l-phe)中发现鸡精是一个二元胺和乙酰胆碱酯酶的抑制剂
A DKP Cyclo(L-Phe-L-Phe) Found in Chicken Essence Is a
Dual Inhibitor of the Serotonin Transporter and
Acetylcholinesterase
1 2 2 3,4 5
Nobuo Tsuruoka *, Yoshinori Beppu , Hirofumi Koda , Nobutaka Doe , Hiroshi Watanabe ,
Keiichi Abe1
1 BRAND’S Brain Research Centre, Cerebos Pacific Limited, Singapore, Singapore, 2 Frontier Center for Value Creation, Suntory Business Expert Limited, Osaka, Japan,
3 Section of Behavioral Science, Kouiken Co. Ltd., Hyogo, Japan, 4 Laboratory of Neurogenesis and CNS Repair, Institute for Advanced Medical Science, Hyogo College of
Medicine, Hyogo, Japan, 5 Institute for Health Care Science, Suntory Wellness Limited, Tokyo, Japan
Abstract
Diketopiperazines (DKPs) are naturally-occurring cyclic dipeptides with a small structure and are found in many organisms
and in large amounts in some foods and beverages. We found that a chicken essence beverage, which is popular among
Southeast Asians as a traditional remedy and a rich source of DKPs, inhibited the serotonin transporter (SERT) and
suppressed serotonin uptake from rat brain synaptosomes, which prompted us to isolate and identify the active
substance(s). We purified a SERT inhibitor from the chicken essence beverage and identified it as the DKP cyclo(L-Phe-L-Phe).
Interestingly, it was a naturally occurring dual inhibitor that inhibited both SERT and acetylcholinesterase (AChE) in vitro.
The DKP increased extracellular levels of the cerebral monoamines serotonin, norepinephrine, and dopamine in the medial
prefrontal cortex and acetylcholine in the ventral hippocampus of freely
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