原创力文档a distinct expression pattern in mammalian testes indicates a conserved role for nanog in spermatogenesis不同的表达模式在哺乳动物睾丸表明nanog在精子形成的保护作用.pdfVIP
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a distinct expression pattern in mammalian testes indicates a conserved role for nanog in spermatogenesis不同的表达模式在哺乳动物睾丸表明nanog在精子形成的保护作用
A Distinct Expression Pattern in Mammalian Testes
Indicates a Conserved Role for NANOG in
Spermatogenesis
1,2,3 4 5 6
Ewart W. Kuijk , Jeffrey de Gier , Susana M. Chuva de Sousa Lopes , Ian Chambers , Ans M. M. van
7 1 1
Pelt , Ben Colenbrander , Bernard A. J. Roelen *
1 Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, 2 Department of Reproductive Medicine and
Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands, 3 Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands,
4 Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands, 5 Department of Anatomy and
Embryology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands, 6 Medical Research Council Centre for Regenerative Medicine, Institute for
Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom, 7 Center for Reproductive Medicine, Department of Obstetrics and
Gynecology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Abstract
Background: NANOG is a key player in pluripotency and its expression is restricted to pluripotent cells of the inner cell mass,
the epiblast and to primordial germ cells. Spermatogenesis is closely associated with pluripotency, because through this
process highly specialized sperm cells are produced that contribute to the formation of totipotent zygotes. Nevertheless, it
is unknown if NANOG plays a role in this process.
Methodology/Principal Findings: In the current study, NANOG expression was examined in testes of vario
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