原创力文档a microrna-7 binding site polymorphism in hoxb5 leads to differential gene expression in bladder cancer在hoxb5 microrna-7结合位点多态性导致膀胱癌的基因差异表达.pdfVIP
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a microrna-7 binding site polymorphism in hoxb5 leads to differential gene expression in bladder cancer在hoxb5 microrna-7结合位点多态性导致膀胱癌的基因差异表达
A MicroRNA-7 Binding Site Polymorphism in HOXB5
Leads to Differential Gene Expression in Bladder Cancer
1 2 3 4 5 1 6 1
Junhua Luo , Qingqing Cai , Wei Wang , Hui Huang , Hong Zeng , Wang He , Weixi Deng , Hao Yu ,
7 7 1 1,6
Eddie Chan , Chi-fai NG , Jian Huang *, Tianxin Lin *
1 Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China, 2 Department of Internal Medicine, Cancer Center, Sun Yat-sen
University, Guangzhou, China, 3 Department of Urology, Guangzhou General Hospital of Guangzhou Military Command (Guangzhou Liuhuaqiao Hospital), Guangzhou,
China, 4 Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China, 5 Department of Pathology, Sun Yat-sen Memorial Hospital,
Sun Yat-sen University, Guangzhou, China, 6 Lin Bai-xin Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China, 7 Division of Urology,
Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China
Abstract
Purpose: To investigate the biological function of HOXB5 in human bladder cancer and explore whether the HOXB5 3 9-UTR
SNP (1010A/G), which is located within the microRNA-7 binding site, was correlated with clinical features of bladder cancer.
Methods: Expression of HOXB5 in 35 human bladder cancer tissues and 8 cell lines were examined using real-time PCR and
immunohistochemistry. Next, we explored the biological function of HOXB5 in vitro using cell proliferation, migration and
colony formation assays. Using bioinformatics, a SNP (1010A/G) was found located within the microRNA-7 binding site in
the 39-UTR of HOXB5. Real-time PCR was used
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