原创力文档a molecular score by quantitative pcr as a new prognostic tool at diagnosis for chronic lymphocytic leukemia patients分子分数定量pcr作为新诊断为慢性淋巴细胞白血病患者预后的工具.pdfVIP
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a molecular score by quantitative pcr as a new prognostic tool at diagnosis for chronic lymphocytic leukemia patients分子分数定量pcr作为新诊断为慢性淋巴细胞白血病患者预后的工具
A Molecular Score by Quantitative PCR as a New
Prognostic Tool at Diagnosis for Chronic Lymphocytic
Leukemia Patients
1 1 ´ 1 1 ´ 2
Basile Stamatopoulos *, Nathalie Meuleman , Cecile De Bruyn , Karlien Pieters , Geraldine Anthoine ,
3 1 1
Philippe Mineur , Dominique Bron , Laurence Lagneaux
´
1 Laboratory of Experimental Hematology, Faculty of Medicine, Institut Jules Bordet, Universite Libre de Bruxelles (ULB), Brussels, Belgium, 2 Department of Intensive Care
´ ˆ
and Thoracic Oncology, Institut Jules Bordet, Universite Libre de Bruxelles (ULB), Brussels, Belgium, 3 Department of Hemato-Oncology, Grand Hopital de Charleroi, Gilly,
Belgium
Abstract
Background: Several markers have been proposed to predict the outcome of chronic lymphocytic leukemia (CLL) patients.
However, discordances exist between the current prognostic factors, indicating that none of these factors are totally perfect.
Methodology/Principal Findings: Here, we compared the prognostic power of new RNA-based markers in order to
construct a quantitative PCR (qPCR) score composed of the most powerful factors. ZAP70, LPL, CLLU1, microRNA-29c and
microRNA-223 were measured by real time PCR in a cohort of 170 patients with a median follow-up of 64 months (range
3-330). For each patient, cells were obtained at diagnosis and RNA was extracted from purified CD19 cells. The best markers
were included in a qPCR scor
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