奥美拉唑镁肠溶片治疗上消化道溃疡出血疗效及不良反应评价.docVIP

奥美拉唑镁肠溶片治疗上消化道溃疡出血疗效及不良反应评价[摘要] 目的：探讨奥美拉唑镁肠溶片治疗上消化道溃疡出血的临床疗效及不良反应。方法：回顾性分析2008年12月～2009年6月我院收治的上消化道溃疡出血患者90例的临床资料，所有患者随机分为两组各45例，对照组采用泮托拉唑钠治疗，观察组采用奥美拉唑镁肠溶片治疗。结果：观察组总有效率为95.6%，明显高于对照组的82.2%，差异有统计学意义（P＜0.05）。两组均未见明显不良反应。结论：应用奥美拉唑镁肠溶片治疗上消化道溃疡出血疗效安全、可靠，值得临床推广。 [关键词] 上消化道溃疡出血；奥美拉唑镁肠溶片；泮托拉唑钠 [中图分类号] R573.1[文献标识码]B [文章编号]1673-7210（2010）11（a）-058－０2 Evaluation of efficacy and adverse reactions of Omeprazole Magnesium Enteric-coared Tablets in the treatment of bleeding of gastroduodenal ulcer WANG Guangcheng, ZHANG Yannan, XU Feng （Department of Pharmacy, the MCH Hospital of Jiamusi City, Heilongjiang Province, Jiamusi 154002, China） [Abstract] Objective: To investigate the efficacy and adverse reactions of Omeprazole Magnesium Enteric-coared Tablets in the treatment of bleeding of gastroduodenal ulcer. Methods: From December 2008 to June 2009 in our hospital, the clinical data of 90 cases with bleeding of gastroduodenal ulcer were retrospectively analyzed, all patients were randomly divided into two groups, each of 45 patients, the control group treated with Pantoprazole sodium, the observation group treated with Omeprazole Magnesium Enteric-coared Tablets. Results: The total effective rate of observation group was 97.62%, it was significantly higher than 82.2% of the control group, there was significant difference between two groups (P＜0.05). There was no significant adverse reactions in both groups. Conclusion: Omeprazole Magnesium Enteric-coared Tablets in the treatment of bleeding of gastroduodenal ulcer is safe, reliable, worthy of clinical application. [Key words] Bleeding of gastroduodenal ulcer; Omeprazole Magnesium Enteric-coared Tablets; Pantoprazole sodium 出血是消化道溃疡常见的并发症，屈氏韧带以上的部分称上消化道，包括食管、胃、十二指肠、上段空肠[1]。本研究主要探讨上消化道溃疡出血的治疗情况，笔者应用奥美拉唑镁肠溶片治疗获得较好疗效，现将相关的临床资料进行总结，报道如下： 1 资料与方法 1.1 一般资料 选择我院2008年12月～2009年6月收治的上消化道溃疡出血患者90例，遵照知情同意原则将所有患者随机分为两组各45例。对照组中，男27例，女18例； 年龄27～69岁，平均（39.2±2.7）岁；胃溃疡14例，十二指肠溃疡20例，其他11例；出血500～1 000 ml，平均（650±50） m