镍N-杂环卡宾配合物在均相催化偶联反应中的应用.PDF

2010 Chinese Journal of Catalysis Vol. 31 No. 8 文章编号: 0253-9837(2010)08-0875-12 国际版DOI: 10.1016/S1872-2067(09)60089-9 综述: 875~886 镍 N -杂环卡宾配合物在均相催化偶联反应中的应用 顾绍金, 倪 鹏, 陈万芝 浙江大学化学系, 浙江杭州 310028 摘要： 近十几年来, N -杂环卡宾的配位化学和金属有机化学发展迅速, 已成为均相催化反应中研究最为广泛的配体之一. 在许多 过渡金属催化的有机合成反应中特别是偶联反应中, N -杂环卡宾与传统有机膦配体相比具有较高的反应性. 镍价格低廉, 在很 多反应中有望替代贵金属钯催化剂. 本文总结了镍 N -杂环卡宾化合物在催化交叉偶联反应和还原偶联反应中的最新应用进展. 关键词：镍; N -杂环卡宾; 交叉偶联反应; 还原偶联; 均相催化 中图分类号：O643 文献标识码：A N-Heterocyclic Carbenes: Versatile Reagents for Nickel-Catalyzed Coupling Reactions * GU Shaojin, NI Peng, CHEN Wanzhi Department of Chemistry, Zhejiang University, Hangzhou 310028, Zhejiang, China Abstract: The chemistry of N-heterocyclic carbenes (NHCs) has grown rapidly in the past decade. NHCs are now important ligands in ho- mogeneous catalysis that show better catalytic activities than the typical phosphines in a number of transition metal catalyzed organic trans- formations, especially in C-C/heteroatom bond formation reactions. Ni is a much cheaper metal and the most promising alternative to Pd, and is receiving increasing attention. In this article we summarize new developments in the catalytic applications of nickel-NHC complexes in coupling reactions that include typical cross couplings of organic halides with various organometallic reagents and reductive coupling reac- tions. Key words: nickel; N-heterocyclic carbene; cross-coupling reaction; reducti