根治幽门螺杆菌感染治疗疗效观察及护理.docVIP

根治幽门螺杆菌感染治疗疗效观察及护理[摘要] 目的：探讨三组用药方案根治幽门螺杆菌（Hp）感染临床疗效的观察与护理。方法：396例经胃镜检查确认为慢性胃炎和消化性溃疡Hp阳性患者，随机分为三组。1组：奥美拉唑20 mg+克拉霉素500 mg+阿莫西林1 000 mg，po，bid；2组：奥美拉唑20 mg+阿莫西林1 000 mg+甲硝唑400 mg，po，bid；3组：奥美拉唑20 mg+阿莫西林1 000 mg+呋喃唑酮100 mg，po，bid。每组132例，均以7 d为1个疗程，用药后，7 d内分别做门诊和电话随访，记录服药后有无不良反应发生。结果：三组Hp根除率：1组为86.12%；2组为59.23%；3组为92.24%，1组和3组比较，无显著性差异（χ2=2.70，P0.05）；2组和1组比较，有非常显著性差异（χ2=39.51，P1组2组。结论：三联疗法有根除Hp作用，无不良反应发生。 [关键词] 幽门螺杆菌；慢性胃炎；消化性溃疡；护理 [中图分类号] R573[文献标识码]Ａ [文章编号]1673-7210（2010）10（a）-030-02 Observation and nursing of eradication of Helicobacter pylori infection WANG Fenjuan, WANG Xin, GE Weiyuan (Qingdao Municipal Hospital, Shandong Province, Qingdao 266071, China) [Abstract] Objective: To observe the three drug regimens eradication of Helicobacter pylori (Hp) infection therapy. Methods: 396 confirmed by endoscopy for chronic gastritis and peptic ulcer Hp-positive patients were randomly divided into three groups. Group 1, Omeprazole 20 mg+Clarithromycin 500 mg+Amoxicillin 1 000 mg, po, bid; group 2, Omeprazole 20 mg+Amoxicillin 1 000 mg+Etronidazole 400 mg, po, bid; group 3, Omeprazole 20 mg+Amoxicillin 1 000 mg+Furazolidone 100 mg, po, bid. 132 cases in each group, there was a course of 7 days after treatment, were done within 7 days of outpatient and telephone follow-up, record adverse reaction after taking place. Results: Three groups of Hp eradication rates as, group 1 of 86.12%; group 2 of 59.23%; group 3 of 92.24%, there was no significant difference between group 1 and 3 (χ2=2.70, P＞0.05), there was a significant difference between group 1 and 2 (χ2=39.51，Pgroup 1group 2. Conclusion: A triple therapy method could have the role of Helicobacter pylori infection and no adverse reaction. [Key words] Helicobacter pylori; Chronic gastritis; Peptic ulcer; Nursing 幽门螺杆菌（Hp）感染与慢性胃炎、消化性溃疡、胃癌以及MLAT淋巴瘤的发生密切相关[1]。因此，根除Hp感染对于防止上述疾病的发生与发展均有至关重要的临床意义。现将2006年1月～2007年1月笔者对396例Hp阳性患者进行Hp根除治疗的情况，就不同的治疗用药做一疗效对比分析，并对治疗中有关护理问题进行初步探讨。 1 资料与方法 1.1 一般资料 本文纳入观察的