布地奈德对咳嗽变异性哮喘诱导痰炎症介质的影响及其临床意义.DOC

审稿意见：1、 本文的研究设计思路清晰，条理较为清楚，有一定的意义，但也有下列不足。2、 文中出现治疗后2个月、治疗后4个月、治疗后8个月和随访4个月后等时间点，有点不太清楚，是否指所有患者均治疗8个月，然后停药再观察4个月，如果是的话，请说明之并请明确治疗8个月的依据是什么？ 答：指所有患者均治疗8个月，然后停药再观察4个月，治疗8个月的依据是根据“我国《咳嗽的诊断与治疗指南》推荐吸入糖皮质激素治疗的时间不能少于 8周”。3、 “CVA复发患者诱导痰IL-6表达水平为62.9?11.3 μg/ml”是指的治疗前的数值还是随访4个月后的数值？ 答：是随访4个月后的数值，已在文中用红色字体标出。建议修改后发表。 您好！文章版幅过长，现在收取版面费将近4000，建立压缩文字修回后再收取版面费。另外表格可否精简。摘要目的。方法 选取患者μg，每天吸入2次，连续吸入8个月治疗;另取我院体检中心健康志愿者40例作为正常对照。对照组和CVA组治疗前、治疗后2个月、治疗后4个月、治疗后8个月、随访4个月后行诱导痰操作，ELISA法检测诱导痰IL-6表达，细胞沉渣涂片检测嗜酸性粒细胞（EOS）比例。结果±12.4 μg/ml，EOS比例为14.7±4.2%，均显著高于健康对照的17.4±3.2 μg/ml和2.3±0.6%（P0.01）。CVA患者治疗前、治疗后2个月、治疗后4个月、治疗后8个月、随访4个月后，各组之间IL-6表达水平和EOS比例存在显著性差异（P0.05）。布地奈德.9±11.3 μg/ml，EOS比例为10.4±2.9%，均显著高于非复发患者的28.3±4.4μg/ml和5.8±1.4%（P0.01）。结论。 关键词The effect of Budesonide on inflammatory factors in induced sputum in patients with cough variant asthma and its clinical significancy Li Ying (Internal Medicine Department 3, the Infectious Disease Hospital of Wangkai ZaoZhuang, Tengzhou, Shandong, 277599) Abstract: Objective To observe the effect of Budesonide on inflammatory factors in induced sputum in patients with cough variant asthma(CVA) and explore its clinical significancy. Methods 84 CVA patients were sellected in this study. Another 40 healthy person were sellected as control. The expression of IL-6 in induced sputum was detected by ELISA analysis. The percent of EOS cells were determined by microscope detection. Results The IL-6 expression induced sputum of CVA patients was 76.5±12.4 μg/ml, and the percent of EOS cells was 14.7±4.2%, which was significant higher than that of 17.4±3.2 μg/ml and 2.3±0.6% in control group (P 0.01). There was significant difference of IL-6 expression and EOS cells percent among pre-treatment, post-treatment for 2 monthes, post-treatment for 4 monthes, post-treatment for 8 monthes, and followed up for 4 monthes(P 0.05). The clinic effective rate was 95.2%, and the recurrence rate was 9.5%. The IL-6 expression induced sputum of recurrence patients was 62.9±11.3 μ