血液灌流治疗急性中毒55例临床分析.docVIP

血液灌流治疗急性中毒55例临床分析[摘要] 目的：探讨采用血液灌流治疗急性中毒的临床疗效。方法：分析我院2008年5月~2010年8月收治的55例急性中毒患者的临床资料，对比患者在采用血液灌流治疗前后生化指标的差异，使用血液灌流抢救急性中毒患者的疗效。结果：55例患者中，治愈45例，治愈率为81.82%，死亡患者10例，所有患者未出现中毒反跳现象。治疗前后生化指标差异明显（P＜0.05）。结论：对于急性重度中毒的患者早期进行血液灌流，可有效提高抢救的成功率。 [关键词] 急性中毒；血液灌流；抢救措施 [中图分类号] R996[文献标识码]Ａ [文章编号]1673-7210（2010）11（c）-027-02 Clinical analysis of blood flow in the treatment of acute poisoning for 55 cases CHEN Jinrong (Department of Kidney Blood Medical, the Wenshanzhou People’s Hospital of Yunnan Province, Wenshan 663000, China) [Abstract] Objective: To study the clinical efficacy of blood perfusion (HP) in the treatment of acute poisoning. Methods: From May 2008 to August 2010 in our hospital, the clinical data of 55 patients with acute poisoning were admitted, the difference of biochemical indicators of blood perfusion before and after treatment of direct bilirubin (DBIL), indirect bilirubin (IBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK) were compared, and to explore the efficacy of hemoperfusion in acute poisoning of patients. Results: Among 55 patients, 45 patients were cured, the cure rate was 81.82%, 10 patients died, all patients had no toxicity against jumps. Biochemical differences before and after treatment were significant (P＜0.05). Conclusion: For patients with acute severe poisoning blood perfusion early stage can effectively improve the success rate of rescue. [Key words] Acute poisoning; Blood perfusion; Rescue measures 急性药物或者毒物中毒在临床上很常见，内科常用的急救措施如催吐、洗胃、利尿、导泻等保守治疗方法基本上可使大部分中毒患者抢救成功，而某些中毒量较大或者就诊时间晚的患者采用上述的治疗方法往往很难抢救成功，毒物在人体内长时间的滞留[1]，所引起的并发症往往会导致患者死亡。现将我院血液透析室采用血液灌流的方法抢救急性中毒患者的临床资料进行分析，效果满意，现报道如下： 1 资料与方法 1.1 一般资料 选取我院2008年5月~2010年8月收治的55例急性中毒患者，其中，男35例，女20例；年龄15~73岁，平均（35.6±3.5）岁。中毒种类：毒蘑菇中毒31例，占56.36%；鱼胆中毒7例，占12.73%；毒鼠强中毒9例，占16.36%；百草枯中毒8例，占14.55%。本组患者均采用血液灌流治疗，患者中毒后至接受血液灌流治疗时间为3~72 h。 1.2 临床表现与中毒的程度 药物中毒时的主要表现是体温、呼吸、血压、脉搏意识状态以及瞳孔等生命体征的改变。毒物（毒鼠强）中毒后生命体征一般较