Cancer的.pptVIP

Cancer Cells Evolveby Natural Selection Variation变异 in the population of cells: Somatic mutations. Variation amongst cells is Heritable可遗传的: Mutations in DNA, chromosomes, methylation甲基化 patterns. Variation affects Reproduction and Survival of the cells: e.g., suppression of apoptosis etc. Progression of Cancer (1) Mutations in genes related to cell cycle, tissue growth, invasion, apoptosis, cellular senescence衰老, cell adhesion, angiogenesis血管再生 (2) Genetic (chromosomal and microsatellite) instability (3) Clonal growth, somatic mutation and selection (usually need 5+ mutations) The Hal