artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure人工选择对整体动物低内在co-segregates有氧能力与低氧诱导心脏泵衰竭.pdfVIP

Artificial Selection for Whole Animal Low Intrinsic Aerobic Capacity Co-Segregates with Hypoxia-Induced Cardiac Pump Failure 1 2 3 3 3 Nathan J. Palpant , Michael L. Szatkowski , Wang Wang , DeWayne Townsend , Fikru B. Bedada , 4 1,4 3 Lauren G. Koch , Steven L. Britton , Joseph M. Metzger * 1 Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America, 2 Division of Neonatology, Drexel University College of Medicine, St. Christopher’s Hospital for Children, Philadelphia, Pennsylvania, United States of America, 3 Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America, 4 Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, Michigan, United States of America Abstract Oxygen metabolism is a strong predictor of the general health and fitness of an organism. In this study, we hypothesized that a divergence in intrinsic aerobic fitness would co-segregate with susceptibility for cardiovascular dysfunction. To test this hypothesis, cardiac function was assessed in rats specifically selected over nineteen generations for their low (LCR) and high (HCR) intrinsic aerobic running capacity. As an integrative marker of native aerobic capacity, run time to exhaustion between LCR and HCR rats had markedly diverged by 436% at generation nineteen of artificial selection. In vivo assessment of baseline cardiac function by echocardiography and catheter-based conductance micromanometry showed no marked difference in cardiac performance