associations of infant nutrition with insulin resistance measures in early adulthood evidence from the barry-caerphilly growth (bcg) study婴儿营养协会与胰岛素抵抗措施在成年早期barry-caerphilly增长(bcg)研究的证据.pdfVIP

Associations of Infant Nutrition with Insulin Resistance Measures in Early Adulthood: Evidence from the Barry- Caerphilly Growth (BCG) Study 1 1 1 2 1 Dylan M. Williams *, Richard M. Martin , George Davey Smith , K. G. M. M. Alberti , Yoav Ben-Shlomo , Anne McCarthy3 1 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom, 2 Department of Endocrinology and Metabolism, St Mary’s Hospital, Imperial College, London, United Kingdom, 3 Child Health Epidemiology Division, Health Research Board, Dublin, Ireland Abstract Background: Previous studies suggest that over-nutrition in early infancy may programme long-term susceptibility to insulin resistance. Objective: To assess the association of breast milk and quantity of infant formula and cows’ milk intake during infancy with insulin resistance measures in early adulthood. Design: Long-term follow-up of the Barry Caerphilly Growth cohort, into which mothers and their offspring had originally been randomly assigned, between 1972–1974, to receive milk supplementation or not. Participants were the offspring, aged 23–27 years at follow-up (n = 679). Breastfeeding and formula/cows’ milk intake was recorded prospectively by nurses. The main outcomes were insulin sensitivity (ISI0) and insulin secretion (CIR30). Results: 573 (84%) individuals had valid glucose and insulin results and complete covariate information. There was little evidence of associations of breastfeeding versus any formula/cows’ milk feeding or of increasing quartiles of formula/cows’ milk consumption during infancy (,3 months) with any outcome measure in young adulthood. In fully adjusted models, the differences in outcomes between breastfeeding versus formula/cows’ m