beneficial effects of a q-ter？ based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats有利影响q-ter 营养混合物基于功能性能、线粒体功能,在大鼠氧化应激.pdfVIP

Beneficial Effects of a Q-terH Based Nutritional Mixture on Functional Performance, Mitochondrial Function, and Oxidative Stress in Rats 1 1 1 1 1 Jinze Xu *, Arnold Y. Seo , Darya A. Vorobyeva , Christy S. Carter , Stephen D. Anton , Angela M. S. 2 1 Lezza , Christiaan Leeuwenburgh * 1 Division of Biology of Aging, Genomics and Biomarkers Core of The Institute on Aging, Department of Aging and Geriatric Research, University of Florida, Gainesville, Florida, United States of America, 2 Department of Biochemistry and Molecular Biology ‘‘E. Quagliariello’’ University of Bari, Bari, Italy Abstract Background: Mitochondrial dysfunction and oxidative stress are central mechanisms underlying the aging process and the pathogenesis of many age-related diseases. Selected antioxidants and specific combinations of nutritional compounds could target many biochemical pathways that affect both oxidative stress and mitochondrial function and, thereby, preserve or enhance physical performance. Methodology/Principal Findings: In this study, we evaluated the potential anti-aging benefits of a Q-terH based nutritional mixture (commercially known as EufortynH) mainly containing the following compounds: terclatrated coenzyme Q10 (Q- terH), creatine and a standardized ginseng extract. We found that EufortynH supplementation significantly ameliorated the age-associated decreases in grip strength and gastrocnemius subsarcolemmal mitochondria Ca2+ retention capacity when initiated in male Fischer344 x Brown Norway rats at 21 months, but not 29 months, of age. Moreover, the increases in muscle RNA oxidation and subsarcolemmal mitochondrial protei