原创力文档biochemical warfare on the reef the role of glutathione transferases in consumer tolerance of dietary prostaglandins生化战争的珊瑚礁中谷胱甘肽转移酶的作用消费者饮食前列腺素公差.pdfVIP
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biochemical warfare on the reef the role of glutathione transferases in consumer tolerance of dietary prostaglandins生化战争的珊瑚礁中谷胱甘肽转移酶的作用消费者饮食前列腺素公差
Biochemical Warfare on the Reef: The Role of
Glutathione Transferases in Consumer Tolerance of
Dietary Prostaglandins
Kristen E. Whalen1¤a*, Amy L. Lane2¤b, Julia Kubanek2,3, Mark E. Hahn1
1 Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, United States of America, 2 School of Chemistry and Biochemistry, Georgia
Institute of Technology, Atlanta, Georgia, United States of America, 3 School of Biology, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Abstract
Background: Despite the profound variation among marine consumers in tolerance for allelochemically-rich foods, few
studies have examined the biochemical adaptations underlying diet choice. Here we examine the role of glutathione S-
transferases (GSTs) in the detoxification of dietary allelochemicals in the digestive gland of the predatory gastropod
Cyphoma gibbosum, a generalist consumer of gorgonian corals. Controlled laboratory feeding experiments were used to
investigate the influence of gorgonian diet on Cyphoma GST activity and isoform expression. Gorgonian extracts and semi-
purified fractions were also screened to identify inhibitors and possible substrates of Cyphoma GSTs. In addition, we
investigated the inhibitory properties of prostaglandins (PGs) structurally similar to antipredatory PGs found in high
concentrations in the Caribbean gorgonian Plexaura homomalla.
Principal Findings: Cyphoma GST subunit composition was invariant and activity was constitutively high regardless of
gorgonian diet. Bioassay-guided fractionation of gorgonian extracts revealed that moderately hydrophobic fractions from
all eight gorgonian species examined contained putative GST substrates/inhibitors. LC-MS and NMR spectral analysis of the
most inhibitory fraction from P. homomalla subse
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