bone turnover and metabolism in patients with early multiple sclerosis and prevalent bone mass deficit a population-based case-control study早期的多发性硬化症患者骨代谢和新陈代谢和普遍的骨量赤字以人群为基础的病例对照研究.pdfVIP

Bone Turnover and Metabolism in Patients with Early Multiple Sclerosis and Prevalent Bone Mass Deficit: A Population-Based Case-Control Study 1 1 2 3 4 Stine Marit Moen *, Elisabeth Gulowsen Celius , Leiv Sandvik , Magritt Brustad , Lars Nordsletten , Erik Fink Eriksen5, Trygve Holmøy6,7 ˚ ˚ 1 Department of Neurology, Oslo University Hospital Ulleval, Oslo, Norway, 2 Section of Epidemiology and Biostatistics, Oslo University Hospital Ulleval, Oslo, Norway, ˚ 3 Department of Community Medicine, University of Tromsø, Tromsø, Norway, 4 Orthopedic Department, Oslo University Hospital Ulleval, Oslo, Norway, 5 Department of Endocrinology, Oslo University Hospital, Oslo, Norway, 6 Department of Neurology, Akershus University Hospital, Lørenskog, Norway, 7 Institute of Clinical Medicine, University of Oslo, Oslo, Norway Abstract Background: Low bone mass is prevalent in ambulatory multiple sclerosis (MS) patients even shortly after clinical onset. The mechanism is not known, but could involve shared etiological risk factors between MS and low bone mass such as hypovitaminosis D operating before disease onset, or increased bone loss after disease onset. The aim of this study was to explore the mechanism of the low bone mass in early-stage MS patients. Methodology/Principal Findings: We performed a population-based case-control study comparing bone turnover (cross- linked N-terminal telopeptide of type 1 collagen; NTX, bone alkaline phosphatase; bALP),