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carotid artery intima-media thickness, carotid plaque and coronary heart disease and stroke in chinese颈动脉内中膜厚度、颈动脉斑块和冠心病和中风
Carotid Artery Intima-Media Thickness, Carotid Plaque
and Coronary Heart Disease and Stroke in Chinese
1,2 2 3 2 4
Kuo-Liong Chien , Ta-Chen Su , Jiann-Shing Jeng , Hsiu-Ching Hsu , Wei-Tien Chang , Ming-Fong
2 2 5
Chen , Yuan-Teh Lee *, Frank B. Hu *
1 Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, 2 Department of Internal Medicine, National Taiwan University
Hospital, Taipei, Taiwan, 3 Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, 4 Department of Emergency Medicine, National Taiwan
University Hospital, Taipei, Taiwan, 5 Department of Nutrition, School of Public Health, Harvard University, Boston, Massachusetts, United States of America
Abstract
Background: Our aim was to prospectively investigate the association between carotid artery intima-media thickness (IMT)
as well as carotid plaque and incidence of coronary heart disease (CHD) and stroke in Chinese, among whom data are
limited.
Methods and Findings: We conducted a community-based cohort study composed of 2190 participants free of
cardiovascular disease at baseline in one community. During a median 10.5-year follow up, we documented 68 new cases of
coronary heart disease and 94 cases of stroke. The multivariate relative risks (RRs) associated with a change of 1 standard
deviation of maximal common carotid IMT were 1.38 (95% confidence interval [CI], 1.12–1.70) for CHD and 1.47 (95% CI,
1.28–1.69) for stroke. The corresponding RRs with internal carotid IMT were 1.47 (95% CI, 1.21–1.79) for CHD and 1.52 (95%
CI, 1.31–1.76) for stroke. Carotid plaque measured by the degree of d
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