原创力文档cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice细胞和行为的影响在成年小鼠颅辐照subventricular区.pdfVIP
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cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice细胞和行为的影响在成年小鼠颅辐照subventricular区
Cellular and Behavioral Effects of Cranial Irradiation of
the Subventricular Zone in Adult Mice
1,2 ´ 3 1,2 4
Franc¸oise Lazarini , Marc-Andre Mouthon , Gilles Gheusi , Fabrice de Chaumont , Jean-Christophe
4 ´ 5,6 5,6 3
Olivo-Marin , Stephanie Lamarque , Djoher Nora Abrous , Franc¸ois D. Boussin , Pierre-Marie
Lledo1,2*
´ ´
1 Institut Pasteur, Laboratory for Perception and Memory, Paris, France, 2 Centre National de la Recherche Scientifique (CNRS) Unite de Recherche Associee (URA), Paris,
´
France, 3 CEA, DSV, iRCM, SCSR, Laboratoire de RadioPathologie, INSERM U967, Fontenay-aux-Roses, France, 4 Institut Pasteur, Unite Analyse d’Images Quantitative, CNRS
´
(URA 2582), Paris, France, 5 INSERM U862, Neurocentre Magendie, Neurogenesis and Pathophysiology group, Bordeaux, France, 6 Universite de Bordeaux, Bordeaux,
France
Abstract
Background: In mammals, new neurons are added to the olfactory bulb (OB) throughout life. Most of these new neurons,
granule and periglomerular cells originate from the subventricular zone (SVZ) lining the lateral ventricles and migrate via the
rostral migratory stream toward the OB. Thousands of new n
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