原创力文档characterization of the entamoeba histolytica ornithine decarboxylase-like enzyme描述的痢疾阿米巴鸟氨酸decarboxylase-like酶.pdfVIP
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characterization of the entamoeba histolytica ornithine decarboxylase-like enzyme描述的痢疾阿米巴鸟氨酸decarboxylase-like酶
Characterization of the Entamoeba histolytica Ornithine
Decarboxylase-Like Enzyme
1 1 1 2 3
Anupam Jhingran , Prasad K. Padmanabhan , Sushma Singh , Krishanpal Anamika , Abhijeet A. Bakre ,
3 1 2 1
Sudha Bhattacharya , Alok Bhattacharya , Narayanaswamy Srinivasan , Rentala Madhubala *
1 School of Life Sciences, Jawaharlal Nehru University, New Delhi, India, 2 Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India, 3 School of
Environmental Sciences, Jawaharlal Nehru University, New Delhi, India
Abstract
Background: The polyamines putrescine, spermidine, and spermine are organic cations that are required for cell growth
and differentiation. Ornithine decarboxylase (ODC), the first and rate-limiting enzyme in the polyamine biosynthetic
pathway, is a highly regulated enzyme.
Methodology and Results: To use this enzyme as a potential drug target, the gene encoding putative ornithine
decarboxylase (ODC)-like sequence was cloned from Entamoeba histolytica, a protozoan parasite causing amoebiasis. DNA
sequence analysis revealed an open reading frame (ORF) of ,1,242 bp encoding a putative protein of 413 amino acids with
a calculated molecular mass of 46 kDa and a predicted isoelectric point of 5.61. The E. histolytica putative ODC-like
sequence has 33% sequence identity with human ODC and 36% identity with the Datura stramonium ODC. The ORF is a
single-copy gene located on a 1.9-Mb chromosome. The recombinant putative ODC pro
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