原创力文档chemokine (c-c motif) ligand 2 (ccl2) in sera of patients with type 1 diabetes and diabetic complications趋化因子(碳碳主题)配体2(ccl2)血清1型糖尿病患者和糖尿病并发症.pdfVIP
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chemokine (c-c motif) ligand 2 (ccl2) in sera of patients with type 1 diabetes and diabetic complications趋化因子(碳碳主题)配体2(ccl2)血清1型糖尿病患者和糖尿病并发症
Chemokine (C-C Motif) Ligand 2 (CCL2) in Sera of
Patients with Type 1 Diabetes and Diabetic
Complications
1,2,3. 3,4. 3 5 6 6
Ruili Guan , Sharad Purohit , Hongjie Wang , Bruce Bode , John Chip Reed , R. Dennis Steed ,
7 3 3 2,3 3,4
Stephen W. Anderson , Leigh Steed , Diane Hopkins , Chun Xia , Jin-Xiong She *
1 Institute of Translational Medicine and School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing, Jiangsu, People’s Republic of China, 2 Department
of Microbiology and Immunology, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China, 3 Center for Biotechnology and
Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America, 4 Department of Pathology, Medical College of Georgia, Augusta, Georgia,
United States of America, 5 Atlanta Diabetes Associates, Atlanta, Georgia, United States of America, 6 Southeastern Endocrine and Diabetes, Atlanta, Georgia, United
States of America, 7 Pediatric Endocrine Associates, Atlanta, Georgia, United States of America
Abstract
Background: Chemokine (C-C motif) ligand 2 (CCL2), commonly known as monocyte chemoattractant protein-1 (MCP-1),
has been implicated in the pathogenesis of many diseases characterized by monocytic infiltration. However, limited data
have been reported on MCP-1 in type 1 diabetes (T1D) and the findings are inconclusive and inconsistent.
Methods: In this study, MCP-1 was measured in the sera from 2,472 T1D patients and 2,654 healthy controls using a
Luminex assay. The rs102
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